The only city in the world that can lay claim to straddling two continents, Istanbul—once known as Constantinople, capital of the Byzantine and then the Ottoman Empire—has for centuries been a bustling metropolis with one foot in Europe and the other in Asia. Istanbul embraces this enviable position with both a certain chaos and inventiveness, ever evolving as one of the world’s most cosmopolitan crossroads. It’s often said that Istanbul is the meeting point of East and West, but visitors to this city built over the former capital of two great empires are likely to be just as impressed by the juxtaposition of old and new. Office towers creep up behind historic palaces, women in chic designer outfits pass others wearing long skirts and head coverings, peddlers’ pushcarts vie with battered old Fiats and shiny BMWs for dominance of the noisy, narrow streets, and the Grand Bazaar competes with modern shopping malls. At dawn, when the muezzin's call to prayer resounds from ancient minarets, there are inevitably a few hearty revelers still making their way home from nightclubs and bars. Most visitors to this sprawling city of more than 14 million will first set foot in the relatively compact Old City, where the legacy of the Byzantine and Ottoman empires can be seen in monumental works of architecture like the brilliant Aya Sofya and the beautifully proportioned mosques built by the great architect Sinan. Though it would be easy to spend days, if not weeks, exploring the wealth of attractions in the historical peninsula, visitors should make sure also to venture elsewhere in order to experience the vibrancy of contemporary Istanbul. With a lively nightlife propelled by its young population and an exciting arts scene that’s increasingly on the international radar—thanks in part to its stint as the European Capital of Culture in 2010—Istanbul is truly a city that never sleeps. It’s also a place where visitors will feel welcome: Istanbul may be on the Bosphorus, but at heart it’s a Mediterranean city, whose friendly inhabitants are effusively social and eager to share what they love most about it.

Composed of nine metropolitan districts, Izmir is the third largest city in Turkey and the country’s second largest port after Istanbul.

Undoubtedly the most extraordinary island in the Aegean, crescent-shape Santorini remains a mandatory stop on the Cycladic tourist route—even if it's necessary to enjoy the sensational sunsets from Ia, the fascinating excavations, and the dazzling white towns with a million other travelers. Called Kállisti (the "Loveliest") when first settled, the island has now reverted to its subsequent name of Thira, after the 9th-century-BC Dorian colonizer Thiras. The place is better known, however, these days as Santorini, a name derived from its patroness, St. Irene of Thessaloniki, the Byzantine empress who restored icons to Orthodoxy and died in 802. You can fly conveniently to Santorini, but to enjoy a true Santorini rite of passage, opt instead for the boat trip here, which provides a spectacular introduction. After the boat sails between Sikinos and Ios, your deck-side perch approaches two close islands with a passage between them. The bigger one on the left is Santorini, and the smaller on the right is Thirassia. Passing between them, you see the village of Ia adorning Santorini's northernmost cliff like a white geometric beehive. You are in the caldera (volcanic crater), one of the world's truly breathtaking sights: a demilune of cliffs rising 1,100 feet, with the white clusters of the towns of Fira and Ia perched along the top. The bay, once the high center of the island, is 1,300 feet in some places, so deep that when boats dock in Santorini's shabby little port of Athinios, they do not drop anchor. The encircling cliffs are the ancient rim of a still-active volcano, and you are sailing east across its flooded caldera. On your right are the Burnt isles, the White isle, and other volcanic remnants, all lined up as if some outsize display in a geology museum. Hephaestus's subterranean fires smolder still—the volcano erupted in 198 BC, about 735, and there was an earthquake in 1956. Indeed, Santorini and its four neighboring islets are the fragmentary remains of a larger landmass that exploded about 1600 BC: the volcano's core blew sky high, and the sea rushed into the abyss to create the great bay, which measures 10 km by 7 km (6 mi by 4½ mi) and is 1,292 feet deep. The other pieces of the rim, which broke off in later eruptions, are Thirassia, where a few hundred people live, and deserted little Aspronissi ("White isle"). In the center of the bay, black and uninhabited, two cones, the Burnt Isles of Palea Kameni and Nea Kameni, appeared between 1573 and 1925. There has been too much speculation about the identification of Santorini with the mythical Atlantis, mentioned in Egyptian papyri and by Plato (who says it's in the Atlantic), but myths are hard to pin down. This is not true of old arguments about whether tidal waves from Santorini's cataclysmic explosion destroyed Minoan civilization on Crete, 113 km (70 mi) away. The latest carbon-dating evidence, which points to a few years before 1600 BC for the eruption, clearly indicates that the Minoans outlasted the eruption by a couple of hundred years, but most probably in a weakened state. In fact, the island still endures hardships: since antiquity, Santorini has depended on rain collected in cisterns for drinking and irrigating—the well water is often brackish—and the serious shortage is alleviated by the importation of water. However, the volcanic soil also yields riches: small, intense tomatoes with tough skins used for tomato paste (good restaurants here serve them); the famous Santorini fava beans, which have a light, fresh taste; barley; wheat; and white-skin eggplants.

Katakolon could not seem less of a cruise port if it tried. A tiny enclave clinging to the western Peloponnese coast, it's a sleepy place except when ships dock. But it's a popular cruise destination because of its proximity to Olympia. Ancient Olympia was one of the most important cities in classical Greece. The Sanctuary of Zeus was the city's raison d'être, and attracted pilgrims from around the eastern Mediterranean, and later the city played host to Olympic Games, the original athletic games that were the inspiration for today's modern sporting pan-planetary meet. At the foot of the tree-covered Kronion hill, in a valley near two rivers, Katakolon is today one of the most popular ancient sites in Greece. If you don't want to make the trip to Olympia, then Katakolon is an ideal place for a leisurely Greek lunch while you watch the fishermen mend their nets, but there's just not much else to do there.

Nothing can prepare you for your first sight of Dubrovnik. Lying 216 km (135 miles) southeast of Split and commanding a jaw-dropping coastal location, it is one of the world's most beautiful fortified cities. Its massive stone ramparts and fortress towers curve around a tiny harbor, enclosing graduated ridges of sun-bleached orange-tiled roofs, copper domes, and elegant bell towers. Your imagination will run wild picturing what it looked like seven centuries ago when the walls were built, without any suburbs or highways around it, just this magnificent stone city rising out of the sea.In the 7th century AD, residents of the Roman city Epidaurum (now Cavtat) fled the Avars and Slavs of the north and founded a new settlement on a small rocky island, which they named Laus, and later Ragusa. On the mainland hillside opposite the island, the Slav settlement called Dubrovnik grew up. In the 12th century the narrow channel separating the two settlements was filled in (now the main street through the Old Town, called Stradun), and Ragusa and Dubrovnik became one. The city was surrounded by defensive walls during the 13th century, and these were reinforced with towers and bastions in the late 15th century.From 1358 to 1808 the city thrived as a powerful and remarkably sophisticated independent republic, reaching its golden age during the 16th century. In 1667 many of its splendid Gothic and Renaissance buildings were destroyed by an earthquake. The defensive walls survived the disaster, and the city was rebuilt in baroque style.Dubrovnik lost its independence to Napoléon in 1808, and in 1815 passed to Austria-Hungary. During the 20th century, as part of Yugoslavia, the city became a popular tourist destination, and in 1979 it was listed as a UNESCO World Heritage Site. During the war for independence, it came under heavy siege. Thanks to careful restoration, few traces of damage remain; however, there are maps inside the Pile and Ploče Gates illustrating the points around the city where damage was done. It’s only when you experience Dubrovnik yourself that you can understand what a treasure the world nearly lost

Split's ancient core is so spectacular and unusual that a visit is more than worth your time. The heart of the city lies within the walls of Roman emperor Diocletian's retirement palace, which was built in the 3rd century AD. Diocletian, born in the nearby Roman settlement of Salona in AD 245, achieved a brilliant career as a soldier and became emperor at the age of 40. In 295 he ordered this vast palace to be built in his native Dalmatia, and when it was completed he stepped down from the throne and retired to his beloved homeland. Upon his death, he was laid to rest in an octagonal mausoleum, around which Split's magnificent cathedral was built.In 615, when Salona was sacked by barbarian tribes, those fortunate enough to escape found refuge within the stout palace walls and divided up the vast imperial apartments into more modest living quarters. Thus, the palace developed into an urban center, and by the 11th century the settlement had expanded beyond the ancient walls.Under the rule of Venice (1420–1797), Split—as a gateway to the Balkan interior—became one of the Adriatic's main trading ports, and the city's splendid Renaissance palaces bear witness to the affluence of those times. When the Habsburgs took control during the 19th century, an overland connection to Central Europe was established by the construction of the Split–Zagreb–Vienna railway line.After World War II, the Tito years saw a period of rapid urban expansion: industrialization accelerated and the suburbs extended to accommodate high-rise apartment blocks. Today the historic center of Split is included on UNESCO's list of World Heritage Sites.

A small, quiet, well-heeled city, Ravenna has brick palaces, cobblestone streets, magnificent monuments, and spectacular Byzantine mosaics. The high point in its civic history occurred in the 5th century, when Pope Honorious moved his court here from Rome. Gothic kings Odoacer and Theodoric ruled the city until it was conquered by the Byzantines in AD 540. Ravenna later fell under the sway of Venice, and then, inevitably, the Papal States.Because Ravenna spent much of its past looking east, its greatest art treasures show that Byzantine influence. Churches and tombs with the most unassuming exteriors contain within them walls covered with sumptuous mosaics. These beautifully preserved Byzantine mosaics put great emphasis on nature, which you can see in the delicate rendering of sky, earth, and animals. Outside Ravenna, the town of Classe hides even more mosaic gems.

Venice is a city unlike any other. No matter how often you've seen it in photos and films, the real thing is more dreamlike than you could imagine. With canals where streets should be, water shimmers everywhere. The fabulous palaces and churches reflect centuries of history in what was a wealthy trading center between Europe and the Orient. Getting lost in the narrow alleyways is a quintessential part of exploring Venice, but at some point you'll almost surely end up in Piazza San Marco, where tourists and locals congregate for a coffee or an aperitif.